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Lisdexamfetamine dimesylate was not clastogenic in the mouse philanthrope marrow micronucleus examen in vivo and was negative when tested in the E. coli and S. typhimurium components of the Ames test and in the L5178Y/TK+- mouse lymphoma assay in vitro. Amphetamine (d- to l-enantiomer pourcentage of 3:1) did not adversely affect fertility or early embryonic development in the rat at discrétion of up to 20 mg/kg/day.
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